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| Pastore,Camilla V; Pirrone,Federica; Mazzola,Silvia; Rizzi,Manuela; Viola,Manuela; Sironi,Giuseppe; Albertini,Mariangela. |
| Mechanical ventilation is essential in intensive care units. However, it may itself induce lung injury. Current studies are based on rodents, using exceptionally large tidal volumes for very short periods, often after a "priming" pulmonary insult. Our study deepens a clinically relevant large animal model, closely resembling human physiology and the ventilator setting used in clinic settings. Our aim was to evaluate the pathophysiological mechanisms involved in alveolo/capillary barrier damage due to mechanical stress in healthy subjects. We randomly divided 18 pigs (sedated with medetomidine/tiletamine-zolazepam and anesthetised with thiopental sodium) into three groups (n=6): two were mechanically ventilated (tidal volume of 8 or 20 ml/kg), the third... |
| Tipo: Journal article |
Palavras-chave: Gelatinases; Mechanical ventilation; Pig; Ventilator induced lung injury (VILI). |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300002 |
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| Faleiro,Mariana Batista Rodrigues; Croce,Giuliana Brasil; Toledo,Denise Caroline; Rodrigues,Marcela Marcondes Pinto; Batista,Aline Carvalho; Damasceno,Adilson Donizeti; Brito,Luiz Augusto Batista; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de. |
| In this study the expression of metalloproteinases 2 (MMP-2) and 9 (MMP-9) in canine normal prostates and with proliferative disorders was evaluated to verify the role of these enzymes in extracellular matrix remodeling (ECM) and in the tissue invasion process. A total of 355 prostatic samples were obtained, from which 36 (10.1%) were normal prostates, 46 (13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%) with proliferative inflammatory atrophy (PIA), 74 (20.8%) with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%) with prostatic carcinoma (PC). Difference in cytoplasmic immunohistochemical staining of MMP-2 and MMP-9 between acinar epithelium and periacinar stroma was found regarding the different diagnosis. The correlation between... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Gelatinases; Benign prostatic hyperplasia; Proliferative inflammatory atrophy; Prostatic intraepithelial neoplasia; Prostatic carcinoma. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000600015 |
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