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	Provedor de dados Genet. Mol. Biol. (2) Autor Spanó,Mário Antônio (2) Antunes,Lusânia Maria Greggi (1) Fragiorge,Edson José (1) Graf,Ulrich (1) Silva,Regildo Márcio Gonçalves da (1) Sousa,Neila Coelho de (1) Mais... Palavra-chave Genotoxicity tests (2) Antigenotoxicity (1) Ascorbic acid (1) Doxorubicin (1) Drosophila melanogaster (1) Micronucleus assay (1) Recombination test (1) SMART (1) Somatic mutation (1) Wing spot test (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Modulatory effects of the antioxidant ascorbic acid on the direct genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster Genet. Mol. Biol. Fragiorge,Edson José; Spanó,Mário Antônio; Antunes,Lusânia Maria Greggi. In this study two different crosses involving the wing cell markers mwh and flr³ (standard (ST) cross and high bioactivation (HB) cross, the latter being characterized by a high constitutive level of cytochrome P450 which leads to an increased sensitivity to a number of promutagens and procarcinogens) were used to investigate the modulatory effects of ascorbic acid (AA) combined with the antitumor agent doxorubicin (DXR) in Drosophila melanogaster. We observed that the two different concentrations of AA (50 or 100 mM) had no effect on spots frequencies, while DXR treatments (0.2 or 0.4 mM) gave positive results for all types of spots, when compared to negative control. For marker-heterozygous (MH) flies, a protective effect was observed with the lower... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ascorbic acid; Doxorubicin; Drosophila melanogaster; Genotoxicity tests; Somatic mutation; Recombination test. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300025 Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster Genet. Mol. Biol. Silva,Regildo Márcio Gonçalves da; Sousa,Neila Coelho de; Graf,Ulrich; Spanó,Mário Antônio. A Mandevilla velutina crude extract was investigated using the mouse micronucleus test (MNT) and the Drosophila melanogaster somatic mutation and recombination test (SMART) using standard (ST) and high bioactivation (HB) crosses. The MNT used 10 mg, 20 mg or 40 mg per 100 g of body weight (bw) of extract with and without 0.2 mg per 100 g bw peritoneal cyclophosphamide. There was no genotoxicity in the negative control or extract only groups and, compared to the cyclophosphamide control, there was a significant reduction in micronucleated polychromatic erythrocytes in all the groups given extract plus cyclophosphamide. For SMART larvae were fed 5 or 10 mg mL-1 of extract for seven days with and without 0.89 mg mL-1 of urethane given on day seven. The ST and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antigenotoxicity; Genotoxicity tests; Micronucleus assay; SMART; Wing spot test. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400023 Registros recuperados: 2 Primeira ... 1 ... Última

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