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	Provedor de dados BJMBR (2) Autor Antunes-Rodrigues,J (1) Borges,B.C. (1) Elias,L.L.K. (1) Rorato,R. (1) Palavra-chave Astrocytes (2) Glial fibrillary acidic protein (2) Calcium (1) Ferritin (1) GFAP (1) Glutamate receptors (1) Glutamine synthetase (1) Iba-1 (1) Intermediate filament dynamics (1) LPS tolerance (1) Microglia (1) Protein phosphorylation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2012 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Glial cell activity is maintained during prolonged inflammatory challenge in rats BJMBR Borges,B.C.; Rorato,R.; Antunes-Rodrigues,J; Elias,L.L.K.. We evaluated the expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), ionized calcium binding adaptor protein-1 (Iba-1), and ferritin in rats after single or repeated lipopolysaccharide (LPS) treatment, which is known to induce endotoxin tolerance and glial activation. Male Wistar rats (200-250 g) received ip injections of LPS (100 µg/kg) or saline for 6 days: 6 saline (N = 5), 5 saline + 1 LPS (N = 6) and 6 LPS (N = 6). After the sixth injection, the rats were perfused and the brains were collected for immunohistochemistry. After a single LPS dose, the number of GFAP-positive cells increased in the hypothalamic arcuate nucleus (ARC; 1 LPS: 35.6 ± 1.4 vs control: 23.1 ± 2.5) and hippocampus (1 LPS: 165.0 ± 3.0 vs control: 137.5... Tipo: Info:eu-repo/semantics/article Palavras-chave: LPS tolerance; Astrocytes; Microglia; Glial fibrillary acidic protein; Iba-1; Glutamine synthetase; Ferritin. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800014 Control of the phosphorylation of the astrocyte marker glial fibrillary acidic protein (GFAP) in the immature rat hippocampus by glutamate and calcium ions: possible key factor in astrocytic plasticity BJMBR The present review describes recent research on the regulation by glutamate and Ca2+ of the phosphorylation state of the intermediate filament protein of the astrocytic cytoskeleton, glial fibrillary acidic protein (GFAP), in immature hippocampal slices. The results of this research are discussed against a background of modern knowledge of the functional importance of astrocytes in the brain and of the structure and dynamic properties of intermediate filament proteins. Astrocytes are now recognized as partners with neurons in many aspects of brain function with important roles in neural plasticity. Site-specific phosphorylation of intermediate filament proteins, including GFAP, has been shown to regulate the dynamic equilibrium between the polymerized and... Tipo: Info:eu-repo/semantics/other Palavras-chave: Astrocytes; Glial fibrillary acidic protein; GFAP; Glutamate receptors; Protein phosphorylation; Calcium; Intermediate filament dynamics. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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