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| Vigo,A.; Duncan,B.B.; Schmidt,M.I.; Couper,D.; Heiss,G.; Pankow,J.S.; Ballantyne,C.M.. |
| To efficiently examine the association of glutamic acid decarboxylase antibody (GADA) positivity with the onset and progression of diabetes in middle-aged adults, we performed a case-cohort study representing the ~9-year experience of 10,275 Atherosclerosis Risk in Communities Study participants, initially aged 45-64 years. Antibodies to glutamic acid decarboxylase (GAD65) were measured by radioimmunoassay in 580 incident diabetes cases and 544 non-cases. The overall weighted prevalence of GADA positivity (³1 U/mL) was 7.3%. Baseline risk factors, with the exception of smoking and interleukin-6 (P £ 0.02), were generally similar between GADA-positive and -negative individuals. GADA positivity did not predict incident diabetes in multiply adjusted (HR =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus; Glutamic acid decarboxylase; Auto-immune diseases; Inflammation; Risk factors. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700007 |
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| Woraharn,Sasimar; Lailerd,Narissara; Sivamaruthi,Bhagavathi Sundaram; Wangcharoen,Wiwat; Sirisattha,Sophon; Chaiyasut,Chaiyavat. |
| L-glutaminase and glutamic acid decarboxylase (GAD) catalyzes the hydrolysis of L-glutamine and glutamate, respectively. L-glutaminase widely used in cancer therapy along with a combination of other enzymes and most importantly these enzymes were used in food industries, as a major catalyst of bioconversion. The current investigation was aimed to screen and select L-glutaminase, and GAD producing lactic acid bacteria (LAB). A total of 338 LAB were isolated from fermented meat, fermented fish, fermented soya bean, fermented vegetables and fruits. Among 338 isolates, 22 and 237 LAB has been found to be positive for L-glutaminase and GAD, respectively. We found that 30 days of incubation at 35 ºC and pH 6.0 was the optimum condition for glutaminase activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: L-glutaminase; Glutamic acid decarboxylase; Lactic acid bacteria and 16S rRNA sequencing. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612014000400022 |
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