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	Provedor de dados Genet. Mol. Biol. (2) Chilean J. Agric. Res. (1) Autor Ada,Ahmet Oguz (1) Alemdar,Yavuz (1) Burgaz,Sema (1) Cabrera-Brandt,Marco A (1) Demirbag,Ali Eba (1) Demiroglu,Canan (1) Efe,Sibel (1) Figueroa,Christian C (1) Fuentes-Contreras,Eduardo (1) Grubisa,Ivana (1) Iscan,Mumtaz (1) Jozic,Tanja (1) Krstic,Slobodan (1) Milasin,Jelena (1) Milicic,Biljana (1) Otasevic,Petar (1) Suzen,Sinan (1) Vucinic,Nada (1) Yilmazer,Meltem (1) Mais... Palavra-chave Glutathione S-transferases (3) 1-hydroxypyrene (1) Atherosclerosis (1) Coke oven workers (1) Cytochrome P450s (1) Detoxification enzymes (1) Esterases (1) Gene polymorphisms (1) Intrinsic rate of increase (1) Monooxygenases (1) Oxidative stress (1) Polycyclic aromatic hydrocarbons (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Journal article (1) Ano 2018 (1) 2010 (1) 2007 (1) País Brazil (2) Chile (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population Genet. Mol. Biol. Grubisa,Ivana; Otasevic,Petar; Vucinic,Nada; Milicic,Biljana; Jozic,Tanja; Krstic,Slobodan; Milasin,Jelena. Abstract Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atherosclerosis; Gene polymorphisms; Glutathione S-transferases; Oxidative stress. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000100035 Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers Genet. Mol. Biol. Ada,Ahmet Oguz; Yilmazer,Meltem; Suzen,Sinan; Demiroglu,Canan; Demirbag,Ali Eba; Efe,Sibel; Alemdar,Yavuz; Burgaz,Sema; Iscan,Mumtaz. Genetic polymorphisms of xenobiotic metabolizing enzymes have been associated with cancer risk. We evaluated the influences of genetic polymorphisms of polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes on urinary 1-hydroxypyrene (1-OHP) excretion in Turkish coke oven workers. Urinary 1-OHP was analyzed by HPLC after enzymatic hydrolysis. Lymphocyte DNA was used for PCR-based genotyping of cytochrome P450 (CYP) polymorphisms (CYP1A1 and CYP1B1) and glutathione S-transferases (GST) polymorphisms (GSTM1, GSTT1 and GSTP1). The mean urinary 1-OHP levels of coke oven workers were significantly higher than that of controls. No significant difference was detected in the mean urinary 1-OHP levels of smokers and non-smokers either for coke oven workers or... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polycyclic aromatic hydrocarbons; 1-hydroxypyrene; Coke oven workers; Cytochrome P450s; Glutathione S-transferases. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400002 Differences in the Detoxification Metabolism between Two clonal Lineages of the Aphid Myzus persicae (Sulzer) (Hemiptera: Aphididae) Reared on Tobacco (Nicotiana tabacum L.) Chilean J. Agric. Res. Cabrera-Brandt,Marco A; Fuentes-Contreras,Eduardo; Figueroa,Christian C. Myzus persicae (Sulzer) is a highly polyphagous aphid species, with a subspecies (M. persicae nicotianae) well adapted to tobacco (Nicotiana tabacum L.). We evaluated the effect of this host plant on the aphid performance and detoxification enzymes, in order to test the participation of xenobiotic metabolism on the ability of this aphid to overcome the tobacco chemical defences. Two genotypes, one corresponding to the only M. persicae nicotianae genotype reported in Chile on tobacco, and one genotype belonging to M. persicae sensu stricto were reared on tobacco and pepper (Capsicum annuum L.), respectively. M. persicae nicotianae showed a significantly higher intrinsic rate of increase (r m) on pepper than on tobacco, and M. persicae s.s. performed... Tipo: Journal article Palavras-chave: Detoxification enzymes; Esterases; Glutathione S-transferases; Monooxygenases; Intrinsic rate of increase. Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392010000400006 Registros recuperados: 3 Primeira ... 1 ... Última

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