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Blood glucose regulation during fasting in rats under food restriction since birth BABT
Vitoriano,Adriana de Souza; Malta,Ananda; Barrena,Helenton Christian; Furlan,Maria Montserrat Diaz Pedrosa; Bazotte,Roberto Barbosa; Gazola,Vilma Godoi.
The effect of severe food restriction since birth on regulation of fasting glycemia in male Wistar rats was investigated. The control group (CG) had free supply of chow, while the restriction group (RG) received 50% of the amount ingested by the CG. The experiments were done in adult (60 days) overnight fasted rats in which glycemia, liver free glucose levels and hepatic glycogen concentration were measured. In part of the experiments in situ liver perfusion was done. The results showed that livers from the RG had higher glycogenolysis rates but lower gluconeogenesis rates from L-alanine (10 mM). Since RG showed maintained glycemia during fasting, it could be concluded that livers from RG produced glucose preferentially from glycogenolysis in detriment of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food restriction; Rats; Liver; Gluconeogenesis; Glycogenolysis.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100009
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Time sequence of changes in the responsiveness of glycogen breakdown to adrenergic agonists in perfused liver of rats with insulin-induced hypoglycemia BJMBR
Vardanega-Peicher,M.; Lopes,G.; Lima,F.B.; Curi,R.; Nakano,L.C.; Bazotte,R.B..
The time-course changes of the responsiveness of glycogen breakdown to a- and ß-adrenergic agonists during insulin-induced hypoglycemia (IIH) were investigated. Blood glucose levels were decreased prior to the alteration in the hepatic responsiveness to adrenergic agonists. The activation of hepatic glucose production and glycogenolysis by phenylephrine (2 µM) and isoproterenol (20 µM) was decreased in IIH. The changes in the responsiveness of glycogen catabolism were first observed for isoproterenol and later for phenylephrine. Hepatic ß-adrenergic receptors showed a higher degree of adrenergic desensitization than did a-receptors. Liver glycogen synthase activity, glycogen content and the catabolic effect of dibutyryl cyclic AMP (the ß-receptor second...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoglycemia; Adrenergic responsiveness; Insulin-induced hypoglycemia; Hepatic glucose production; Glycogenolysis.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700011
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Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats BJMBR
Machado,E.F.A.; Normand,A.C.R.; Nunes,L.A.S.; Brenzikofer,R.; Macedo,D.V..
Anesthetics can affect the structure and biological function of tissues and systems differentially. The aim of the present study was to compare three injectable anesthetics generally used in experiments with animals in terms of the degree of hemolysis and glycogenolysis occurring after profound anesthesia. Twenty-four male Wistar rats (330-440 g) were divided into three groups (N = 8): chloral hydrate (CH), ketamine + xylazine (KX), Zoletil 50® (zolazepam and tiletamine) + xylazine (ZTX). After deep anesthesia, total blood was collected. The liver and white (WG) and red gastrocnemius (RG) muscles were also immediately removed. The degree of serum hemolysis was quantified on the basis of hemoglobin concentration (g/L). Hepatic and muscular glycogen...
Tipo: Info:eu-repo/semantics/other Palavras-chave: General anesthetic; Rats; Glycogenolysis; Hemolysis; Zoletil; Ketamine.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100006
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Seasonal changes in carbohydrate metabolism and its relationship with summer mortality of Pacific oyster Crassostrea gigas (Thunberg) in Marennes-Ole'ron bay (France) ArchiMer
Soletchnik, Patrick; Faury, Nicole; Goulletquer, Philippe.
This paper investigates the biological responses of Crassostrea gigas under traditional culture conditions on a mudflat in Marennes-Oleron bay. Summer mortality has been regularly observed in recent years in oysters reared using "on bottom" culture conditions. The present study attempts to provide a better understanding of the mortality phenomenon through biological parameters. Classical 'field parameters' such as mortality and growth rates, and quality index (dry meat weight/ dry shell weight x 1000) were monitored. Additional parameters, as biochemical composition of oyster meat and glucose incorporation capacity, were included as potential new bioindicators. The work highlighted a critical timing (May-June) preceding the summer mortality and...
Tipo: Text Palavras-chave: Marennes Oleron bay; Glycogenolysis; In vivo; Glycogen incorporation; Maturation; Summer mortality; Crassostrea gigas.
Ano: 2006 URL: http://archimer.ifremer.fr/doc/2006/publication-1116.pdf
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