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| PAZIN,WALLANCE M.; SANTOS,SUIKINAI N. DOS; QUEIROZ,SONIA C.N.; BAGATOLLI,LUIS A.; SOARES,ADEMILSON E.E.; MELO,ITAMAR S. DE; ITO,AMANDO S.. |
| Abstract: We have established how natural compounds from green propolis collected by the species Apis mellifera act against the growth of Pythium aphanidermatum. On the basis of mass spectrometry (Q-ToF MS), we determined that Artepillin C, the major constituent of green propolis, underlies the effect and displays activity against P. aphanidermatum at a minimal inhibitory concentration of 750 µg.mL-1. Biophysical studies based on model membranes showed that this inhibitory effect may be linked with a membrane-related phenomenon: Artepillin C increases the permeability of membranes with relatively high fluidity in their lateral structure, a feature that is in line with the lipid composition reported for the cytoplasmic membrane of P. aphanidermatum.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Green propolis; Artepillin C; Fungicide; Pythium aphanidermatum; Model membranes. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300617 |
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| Pazin,W.M.; Vilanova,N.; Voets,I.K.; Soares,A.E.E.; Ito,A.S.. |
| It has been hypothesized that the therapeutic effects of artepillin C, a natural compound derived from Brazilian green propolis, are likely related to its partition in the lipid bilayer component of biological membranes. To test this hypothesis, we investigated the effects of the major compound of green propolis, artepillin C, on model membranes (small and giant unilamelar vesicles) composed of ternary lipid mixtures containing cholesterol, which display liquid-ordered (lo) and liquid-disordered (ld) phase coexistence. Specifically, we explored potential changes in relevant membrane parameters upon addition of artepillin C presenting both neutral and deprotonated states by means of small angle X-ray scattering (SAXS), differential scanning calorimetry... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artepillin C; Green propolis; Model membranes; Giant unilamellar vesicles; SAXS; DSC. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300610 |
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| Martini,Daiane; Barbosa,Giselle Feliciani; Matias,Rosemary; Marques Filho,Wolff Camargo; Garcia,Nayara Zielasko Trombini. |
| ABSTRACT: Apis melífera L. propolis is a resinous and balsamic material whose biological effects are related to its chemical composition. This chemical composition is greatly influenced by seasonality, so propolis from different seasons and regions has a different chemical composition. The increasing need for natural options to control fungi that cause damage to food crops makes propolis an alternative that deserves more research. In this context, the aim of this study was to evaluate the effect of seasonality on the antifungal potential of propolis collected in Campo Grande, Mato Grosso do Sul, Brazil, on the fungus Lasiodiplodia theobromae . Effects of different concentrations of ethanolic extracts of green propolis on the mycelial growth of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lasiodiplodia theobromae; Alternative control; Time of collection; Green propolis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000300404 |
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