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	Provedor de dados BJMBR (2) Autor Fonteles,M.C. (2) Carvalho,A.F. (1) Forte,L.R. (1) Lima,A.A.M. (1) Santos-Neto,M.S. (1) Palavra-chave Guanylin (2) ANP (1) CGMP (1) Electrolyte and water balance (1) Guanylyl cyclase (1) Heat-stable enterotoxin (1) Kidney (1) Kidney function (1) Natriuresis (1) Secretory diarrhea (1) Uroguanylin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Relationship between the actions of atrial natriuretic peptide (ANP), guanylin and uroguanylin on the isolated kidney BJMBR Santos-Neto,M.S.; Carvalho,A.F.; Forte,L.R.; Fonteles,M.C.. Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins. In the kidney, both of them have well-documented natriuretic and kaliuretic effects. Since atrial natriuretic peptide (ANP) also has a natriuretic effect mediated by cGMP, experiments were designed in the isolated perfused rat kidney to identify possible synergisms between ANP, guanylin and uroguanylin. Inulin was added to the perfusate and glomerular filtration rate (GFR) was determined at 10-min intervals. Sodium was also determined. Electrolyte dynamics were measured by the clearance formula. Guanylin (0.5 µg/ml, N = 12) or uroguanylin... Tipo: Info:eu-repo/semantics/article Palavras-chave: ANP; Guanylin; Uroguanylin; Kidney; Natriuresis; CGMP. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800012 From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones BJMBR Lima,A.A.M.; Fonteles,M.C.. The isolation of heat-stable enterotoxin (STa) from Escherichia coli and cholera toxin from Vibrio cholerae has increased our knowledge of specific mechanisms of action that could be used as pharmacological tools to understand the guanylyl cyclase-C and the adenylyl cyclase enzymatic systems. These discoveries have also been instrumental in increasing our understanding of the basic mechanisms that control the electrolyte and water balance in the gut, kidney, and urinary tracts under normal conditions and in disease. Herein, we review the evolution of genes of the guanylin family and STa genes from bacteria to fish and mammals. We also describe new developments and perspectives regarding these novel bacterial compounds and peptide hormones that act in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heat-stable enterotoxin; Guanylin; Guanylyl cyclase; Secretory diarrhea; Kidney function; Electrolyte and water balance. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300179 Registros recuperados: 2 Primeira ... 1 ... Última

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