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	Provedor de dados Genet. Mol. Biol. (1) Autor Mohseni,Jafar (1) Sasongko,Teguh Haryo (1) Zabidi-Hussin,Z.A.M.H. (1) Palavra-chave HDACi (1) Molecular therapy (1) Spinal muscular atrophy (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy Genet. Mol. Biol. Mohseni,Jafar; Zabidi-Hussin,Z.A.M.H.; Sasongko,Teguh Haryo. Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field. Tipo: Info:eu-repo/semantics/article Palavras-chave: HDACi; Molecular therapy; Spinal muscular atrophy. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001 Registros recuperados: 1 Primeira ... 1 ... Última

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