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	Provedor de dados 60 (1) Autor El-ghobashy,Mohamed Refaat (1) Helmy,Aya Helmy (1) Yehia,Ali Mohamed (1) Youssef,Nadia Fayek (1) Palavra-chave Gliquidone/forced degradation/stability-indicating (1) HPLC/method validation (1) TLC/method validation. (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Forced degradation of gliquidone and development of validated stability-indicating HPLC and TLC methods 60 El-ghobashy,Mohamed Refaat; Yehia,Ali Mohamed; Helmy,Aya Helmy; Youssef,Nadia Fayek. Forced degradation studies of gliquidone were conducted under different stress conditions. Three degradates were observed upon using HPLC and TLC and elucidated by LC-MS and IR. HPLC method was performed on C18 column using methanol-water (85:15 v/v) pH 3.5 as a mobile phase with isocratic mode at 1 mL.min-1 and detection at 225 nm. HPLC analysis was applied in range of 0.5-20 µg.mL-1 (r =1) with limit of detection (LOD) 0.177 µg.mL-1. TLC method was based on the separation of gliquidone from degradation products on silica gel TLC F254 plates using chloroform-cyclohexane-glacial acetic acid (6:3:1v/v) as a developing system with relative retardation 1.15±0.01. Densitometric measurements were achieved in range of 2 -20 µg /band at 254 nm (r = 0.9999) with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gliquidone/forced degradation/stability-indicating; HPLC/method validation; TLC/method validation.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300603 Registros recuperados: 1 Primeira ... 1 ... Última

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