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| Freitas,Karine M. de; Almeida,Jacqueline M.; Monteiro,Juliana C.; Diamante,Maria Aparecida S.; Vale,Jéssica S.F. do; Camargo,Camila; Jorge,Marçal H.A.; Dolder,Heidi. |
| Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosais a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa(administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosainfusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosaadministered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatotoxicity; Heteropterys aphrodisiaca; Medicinal plant; Phytotherapy; Hepatotoxicidade; Heteropterys aphro disiaca; Planta medicinal; Fitoterapia. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100369 |
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