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Ríos de Molina,M.C.; Mazzetti,M.B.; Galigniana,M.; Aldonatti,C.; Tomio,J.M.; San Martín de Viale,L.C.. |
We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with hepatic damage. Twenty-five percent of the animals receiving ethanol increased up to 14-, 25-, and 4.5-fold the urinary excretion of delta-aminolevulinate, porphobilinogen, and porphyrins, respectively. Ethanol exacerbated the precursor excretions elicited by hexachlorobenzene. Hepatic porphyrin levels increased by hexachlorobenzene treatment, while this parameter only increased (up to 90-fold) in some of the animals that received ethanol alone. Ethanol reduced the activities of uroporphyrinogen... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alcoholism; Ethanol; Heme metabolic pathway; Hepatic damage; Hexachlorobenzene; Porphyria cutanea tarda. |
Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100004 |
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