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| Kano,Eunice Kazue; Koono,Eunice Emiko Mori; Schramm,Simone Grigoleto; Serra,Cristina Helena dos Reis; Abib Junior,Eduardo; Pereira,Renata; Freitas,Márcia Sayuri Takamatsu; Iecco,Maria Cristina; Porta,Valentina. |
| Average bioequivalence of two 500 mg levofloxacin formulations available in Brazil, Tavanic(c) (Sanofi-Aventis Farmacêutica Ltda, Brazil, reference product) and Levaquin(c) (Janssen-Cilag Farmacêutica Ltda, Brazil, test product) was evaluated by means of a randomized, open-label, 2-way crossover study performed in 26 healthy Brazilian volunteers under fasting conditions. A single dose of 500 mg levofloxacin tablets was orally administered, and blood samples were collected over a period of 48 hours. Levofloxacin plasmatic concentrations were determined using a validated HPLC method. Pharmacokinetic parameters Cmax, Tmax, Kel, T1/2el, AUC0-t and AUC0-inf were calculated using noncompartmental analysis. Bioequivalence was determined by calculating 90%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Levofloxacin/bioequivalence; Pharmacokinetics; High-performance liquid chromatography/qualitative analysis; Tavanic(c)/bioequivalence; Levaquin(c)/bioequivalence. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100203 |
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| Silva,Hilris Rocha e; Santos,Fernanda Kolenyak dos; Luz,Gabriela Marielli da; Chorilli,Marlus; Gremião,Maria Palmira Daflon. |
| In recent decades, there has been a significant increase in the incidence of fungal diseases. Certain fungal diseases cause cutaneous lesions and in the usual treatment, generally administred orally, the drug reaches the site of action with difficulty and its concentration is too low. An approach much explored in recent years is the development of nanotechnology-based drug delivery systems, and microemulsions (ME) and liquid crystals (LC) are promising. ME and LC were developed with oleic acid or copaiba oil as the oil phase, propoxyl (5OP) ethoxyl (20 OE) cetyl alcohol as surfactant and water. An analytical method to assess the incorporation of fluconazole (FLU) in the systems under study was validated according to guidelines of the International... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanotehcnology; Microemulsions; Liquid crystals; High-performance liquid chromatography/qualitative analysis; Fluconazole. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200381 |
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