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Analysis of chlorpheniramine in human urine samples using dispersive liquid-liquid microextraction combined with high-performance liquid chromatography BJPS
Maham,Mehdi; Kiarostami,Vahid; Waqif-Husain,Syed; Sharifabadi,Malihe Khoeini.
A simple and environmentally friendly microextraction technique was used for determination of chlorpheniramine (CPM), an antihistamine drug, in human urine samples using dispersive liquid-liquid microextraction (DLLME) followed by high performance liquid chromatography with diode array detection (HPLC-DAD). In this extraction technique, an appropriate mixture of acetonitrile (disperser solvent) and carbon tetrachloride (extraction solvent) was rapidly injected into the urine sample containing the target analyte. Tiny droplets of extractant were formed and dispersed into the sample solution and then sedimented at the bottom of the conical test tube by centrifugation. Under optimal conditions, the calibration curve was linear in the range of 0.055-5.5 µg...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlorpheniramine/determination in human urine; High-performance liquid chromatography/quantitative analysis; Dispersive liquid-liquid microextraction/quantitative analyisis; Antihistamines; Human urine/analysis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300551
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Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers BJPS
Yan,Xi-Qing; Chen,Zhi-Gang; Wang,Rong-Liang; Yang,Jun; Ai,Fang; Pan,Yan-Juan; Qiu,Pei-Yong; Wang,Da-Xin.
The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diltiazem hydrochloride/delay-onset sustained-release pellet capsules; Diltiazem hydrochloride/pharmacokinetics; Food/ingestion; Food/effect in pharmacokinetic profile; High-performance liquid chromatography/quantitative analysis.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100004
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