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การกระตุ้นการสะสมสารเออโกไธโอนีอีนในเห็ดขอน (Lentinus spp.) และเห็ดน้ำหมึก (Coprinus comatus) โดยใช้วัสดุเพาะผสมฮิสทิดีน Thai Agricultural
Wandee Vangkapun; Khomsorn Lomthaisong; Niwat Sanoamuang.
Growth characteristics and fruiting on histidine (His) amended PDA and levels of L-ergothioneine (ERG) in fruiting bodies of various mushroom species were determined. It was found that growth and mycelial density of some mushroom species were interfered with the higher concentrations of His and the ability to produce fruiting bodies of some species was impaired. The addition of 500 mg/L in PDA produced slender mycelial density of khon mushrooms species such as Lentinus conatus and Lentinus villosus. The levels of ERG accumulated in fruiting bodies depended on mushroom species. The addition of ≤100 mg/L stimulated inkcap mushroom (Coprinus comatus) to accumulate ERG but did not in khon mushrooms (Lentinus polychrous and Lentinus squarrosulus). Taking these...
Tipo: Collection Palavras-chave: Coprinus comatus; Lentinus spp.; Histidine; L-ergothioneine; เห็ดขอน; เห็ดน้ำหมึก; ฮีสทิดีน; เออโกไธโอนีอีน; วัสดุเพาะ; การเจริญเติบโตของเส้นใย; การสร้างดอกเห็ด.
Ano: 2011 URL: http://anchan.lib.ku.ac.th/agnet/handle/001/5205
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Histidines 13 and 14 in the Aβ sequence are targets for inhibition of Alzheimer's disease Aβ ion channel and cytotoxicity Biol. Res.
DÍAZ,JUAN CARLOS; LINNEHAN,JOHN; POLLARD,HARVEY; ARISPE,NELSON.
The fact that Alzheimer's beta amyloid (Aβ) peptides forms cation channels in lipid bilayers was discovered during the course of our experiments in the laboratory of "Guayo" Rojas at NIH in Bethesda, Maryland (USA). Recently, we found that the Aβ ion channel could be blocked selectively with small peptides that copy the amino acid sequence of the predicted mouth region of the Aβ channel pore. We now have searched for the essential amino acid residues required for this blocking effect by mutations. We found that the ability of peptides to block Aβ channel activity could be lost by replacement of histidines 13 and 14 by alanine or lysine. The amino acid substitution also resulted in the loss of the capacity of the peptides...
Tipo: Journal article Palavras-chave: Alzheimer's disease; Beta amyloid; Ion channel blockers; Peptides; Histidine; Toxicity.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300007
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Membrane adsorber for endotoxin removal BJPS
Almeida,Karina Moita de; Almeida,Maiara Maciel; Fingola,Fernando Faria; Ferraz,Helen Conceição.
ABSTRACT The surface of flat-sheet nylon membranes was modified using bisoxirane as the spacer and polyvinyl alcohol as the coating polymer. The amino acid histidine was explored as a ligand for endotoxins, aiming at its application for endotoxin removal from aqueous solutions. Characterization of the membrane adsorber, analysis of the depyrogenation procedures and the evaluation of endotoxin removal efficiency in static mode are discussed. Ligand density of the membranes was around 7 mg/g dry membrane, allowing removal of up to 65% of the endotoxins. The performance of the membrane adsorber prepared using nylon coated with polyvinyl alcohol and containing histidine as the ligand proved superior to other membrane adsorbers reported in the literature. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endotoxins/removal; Membrane adsorber/performance; Histidine; Poly(vinyl alcohol)..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100019
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