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| Ramos-da-Silva,S.; Elgui-de-Oliveira,D.; Borges,L.; Bacchi,C.E.. |
| Kaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described: classical KS, endemic KS, iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been detected worldwide at frequencies ranging from 80 to 100%. The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the current knowledge about KS transmission and detection. For these purposes, DNA from 51 cases of KS was assessed by PCR: 20 (39.2%) cases of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Kaposi's sarcoma; Human herpesvirus type 8; Kaposi's sarcoma-associated herpesvirus; Polymerase chain reaction; Viral carcinogenesis; Brazil. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500002 |
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| Keller,R.; Zago,A.; Viana,M.C.; Bourboulia,D.; Desgranges,C.; Casseb,J.; Moura,W.V.; Dietze,R.; Collandre,H.. |
| The aims of the present study were to determine the prevalence of human herpesvirus type 8 (HHV-8) in HIV-positive Brazilian patients with (HIV+/KS+) and without Kaposi's sarcoma (HIV+/KS-) using PCR and immunofluorescence assays, to assess its association with KS disease, to evaluate the performance of these tests in detecting HHV-8 infection, and to investigate the association between anti-HHV-8 antibody titers, CD4 counts and staging of KS disease. Blood samples from 66 patients, 39 HIV+/KS+ and 27 HIV+/KS-, were analyzed for HHV-8 viremia in peripheral blood mononuclear cells by PCR and HHV-8 antigenemia for latent and lytic infection by immunofluorescence assay. Positive samples for latent nuclear HHV-8 antigen (LNA) antibodies were titrated out from... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS-related Kaposi's sarcoma; Human herpesvirus type 8; HHV-8; Brazil. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700007 |
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