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	Provedor de dados BJPS (1) Autor Girard-Dias,Wendell (1) Guerreiro,Luiz Henrique (1) Lima,Luís Mauricio Trambaioli da Rocha e (1) Mascarenhas,Camile Moreira (1) Miranda,Kildare (1) Ricci Júnior,Eduardo (1) Silva,Daniel da (1) Sola-Penna,Mauro (1) Mais... Palavra-chave Human insulin/study (1) Microparticles (1) Poly-ε-caprolactone (1) Proteins/molecular entrapping (1) Therapeutic proteins/study/action (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study BJPS Guerreiro,Luiz Henrique; Silva,Daniel da; Girard-Dias,Wendell; Mascarenhas,Camile Moreira; Miranda,Kildare; Sola-Penna,Mauro; Ricci Júnior,Eduardo; Lima,Luís Mauricio Trambaioli da Rocha e. ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (PCL) particle system loaded with human insulin using a simple double-emulsion w/o/w method followed by solvent evaporation method. This formulation is comprised by spheric-shaped microparticles with average size of 10 micrometers. In vitro release showed a biphasic behavior such as a rapid release with about 50% of drug delivered within 2 hours and a sustained phase for up to 48 h. The subcutaneous administration of microencapsulated insulin showed a biphasic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human insulin/study; Microparticles; Poly-ε-caprolactone; Therapeutic proteins/study/action; Proteins/molecular entrapping. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200622 Registros recuperados: 1 Primeira ... 1 ... Última

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