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| Odeniyi,Michael Ayodele; Babalola,Adepeju Oluwadamilare; Ayorinde,John Oluwasogo. |
| The compressional, mechanical and bioadhesive properties of tablet formulations incorporating a new gum obtained from the incised trunk of the Cedrela odorata tree were evaluated and compared with those containing hydroxypropylmethylcellulose (HPMC). Compressional properties were evaluated using Hausner's ratio, Carr's Index, the angle of repose, and Heckel, Kawakita and Gurnham plots. Ibuprofen tablets were prepared using the wet granulation method. Bioadhesive studies were carried out using the rotating cylinder method in either phosphate buffer pH 6.8 or 0.1 M hydrochloric acid media. The gum is a low viscosity polymer (48 cPs), and Fourier transform infrared spectroscopy revealed the presence of a hydroxyl group. Py and Pk values, which are measures of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cedrela gum/evaluation; Cedrela gum/compression properties; Cedrela gum/bioadhesive component; Tablet formulations; Hydroxypropylmethylcellulose; Ibuprofen tablets/bioadhesive studies; Bioadhesion. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100011 |
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| Rotta,Jefferson; Minatti,Edson; Barreto,Pedro Luiz Manique. |
| In this work, the structural, mechanical, diffractometric, and thermal parameters of chitosan-hydroxypropylmethylcellulose (HPMC) films plasticized with sorbitol were studied. Solutions of HPMC (2% w/v) in water and chitosan (2% w/v) in 2% acetic acid solution were prepared. The concentration of sorbitol used was 10% (w/w) to both polymers. This solutions were mixed at different proportions (100/0; 70/30; 50/50; 30/70, and 0/100) of chitosan and HPMC, respectively, and 20 mL was cast in Petri dishes for further analysis of dried films. The miscibility of polymers was assessed by X-ray diffraction, scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). The results obtained indicate that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Films; Chitosan; Hydroxypropylmethylcellulose; Physico-chemical properties. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612011000200026 |
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