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	Provedor de dados BJPS (3) Biol. Res. (1) Electron. J. Biotechnol. (1) Autor Aragón,Diana Marcela (1) Bustos-Obregón,Eduardo (1) Fuentefria,Alexandre Meneghello (1) Gottemukkala,Vijay V (1) Hartley,Ricardo (1) Kadari,Anil K (1) Martínez,Fleming (1) Mezzari,Adelina (1) Neau,Steven H (1) Pippi,Bruna (1) Rocha,Letícia Fernandes da (1) Rosas,Jaiver Eduardo (1) Saripella,Kalyan K (1) Sousa,João J. S. (1) Vargas,Álvaro (1) Vaz,Mafalda. B. (1) Vitorino,Carla (1) Mais... Palavra-chave Ibuprofen (5) Cryptococcus neoformans (1) Enantioselective (1) Epididymal sperm (1) Esterification (1) Fluconazole (1) Itraconazole (1) Lipase (1) Mechanical properties (1) Melatonin (1) Mouse (1) Organic solvents (1) Permeation studies (1) Safe-by-design (1) Solubility (1) Solution thermodynamics (1) Solvent-effect (1) Synergism (1) Topical patches (1) Transfer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Journal article (2) Ano 2020 (2) 2011 (1) 2010 (1) 2008 (1) País Brazil (3) Chile (2) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin Biol. Res. Vargas,Álvaro; Bustos-Obregón,Eduardo; Hartley,Ricardo. Hypobaric hypoxia is of interest due to an increase of human populations working at high altitude. Testicular damage is related to the physiological response (neoangiogenesis) to increased intrascrotal blood flow as temperature rises. Hypoxia is a stress factor with overproduction of reactive oxygen species (ROS). The effect of hypoxia in mice reproductive parameters is analyzed. Animals were exposed to simulated hypoxia of 4,200 meters above sea level (m.a.s.l.) in a chamber for 33.2 days, both to continuous (HH) or intermittent hypoxia (HI) with an intermittency period of 4 days hypoxia /4 days normoxia (500 m.a.s.l.). The anti-inflammatory drug Ibuprofen was administered to a group of mice to control vasodilation and increased blood flow. Melatonin was... Tipo: Journal article Palavras-chave: Epididymal sperm; Mouse; Ibuprofen; Melatonin. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200008 Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans BJPS Rocha,Letícia Fernandes da; Pippi,Bruna; Fuentefria,Alexandre Meneghello; Mezzari,Adelina. The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Ibuprofen; Itraconazole; Fluconazole; Synergism. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100577 Safe-by-design development of a topical patch for drug delivery BJPS Vaz,Mafalda. B.; Vitorino,Carla; Sousa,João J. S.. Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a monolithic hydrogel for ibuprofen skin delivery, in order to provide a safer and accurate way of drug administration along with improved treatment compliance. Topical patches based on hydroxypropylmethylcellulose (HPMC) were optimized in composition, in terms of enhancer and adhesive, supported on a systematic assessment of in vitro release and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Topical patches; Ibuprofen; Mechanical properties; Permeation studies; Safe-by-design. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100626 Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane BJPS Aragón,Diana Marcela; Rosas,Jaiver Eduardo; Martínez,Fleming. Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ibuprofen; Solubility; Transfer; Solution thermodynamics; Organic solvents. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200009 Effect of methyl branching of C8H18 alkanes and water activity on lipase-catalyzed enantioselective esterification of ibuprofen Electron. J. Biotechnol. Gottemukkala,Vijay V; Saripella,Kalyan K; Kadari,Anil K; Neau,Steven H. The purpose of this research was to study the effect of the methyl branching of a high log P alkane solvent and the water activity in the organic medium on the initial rate and the enantioselectivity of ibuprofen esterification catalyzed by Candida rugosa lipase. Resolution of ibuprofen is important because S-(+)-ibuprofen has the desired pharmacological activity, whereas the R-(-)-enantiomer causes much of the side effects. The Candida rugosa lipase-catalyzed reaction in isooctane at 40ºC and 0.73 water activity gave the best results, both in terms of the initial reaction rate and the enantioselectivity of the reaction. An increase in water activity allowed a higher reaction rate and enantiomeric excess in each of the four solvents. An increase in methyl... Tipo: Journal article Palavras-chave: Enantioselective; Esterification; Ibuprofen; Lipase; Solvent-effect; Water activity. Ano: 2008 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000100002 Registros recuperados: 5 Primeira ... 1 ... Última

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