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Thalassophryne nattereri fish venom: from the envenoming to the understanding of the immune system J. Venom. Anim. Toxins incl. Trop. Dis.
Lopes-Ferreira,Monica; Grund,Lidiane Zito; Lima,Carla.
Thalassophryne nattereri (niquim) is a venomous fish found off North and Northeast coast of Brazil, where it is known by the severity of the accidents involving humans. This review article is divided into four topics. The first one provides a brief description of the animal biology and its distribution off Brazilian coastal waters, the venom apparatus, signs and symptoms observed in envenomated humans and also describes envenomation in mice. The second topic describes the use of modern genetic approach and mass spectrometry for identification of highly expressed genes in its venom glands and the sequence of major toxins. The third chapter offers a detailed study of tissue injury induced by the venom and reveals the role of toxins that impair inflammation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venomous fish; Thalassophryne nattereri; Immunological memory; Nattectin; Natterin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200208
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Linking immunity and hematopoiesis by bone marrow T cell activity BJMBR
Monteiro,J.P.; Bonomo,A..
Two different levels of control for bone marrow hematopoiesis are believed to exist. On the one hand, normal blood cell distribution is believed to be maintained in healthy subjects by an "innate" hematopoietic activity, i.e., a basal intrinsic bone marrow activity. On the other hand, an "adaptive" hematopoietic state develops in response to stress-induced stimulation. This adaptive hematopoiesis targets specific lineage amplification depending on the nature of the stimuli. Unexpectedly, recent data have shown that what we call "normal hematopoiesis" is a stress-induced state maintained by activated bone marrow CD4+ T cells. This T cell population includes a large number of recently stimulated cells in normal mice whose priming requires the presence of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: T cell; Hematopoiesis; Innate immunity; Adaptive immunity; Bone marrow; Immunological memory.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000004
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