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	Provedor de dados BJPS (3) Autor Beg,Sarwar (1) Gaikwad,Naresh Janardan (1) Hasnain,MS (1) Kandhasami,Uma Devi Subbaih (1) Kohli,Kanchan (1) Nayak,Amit Kumar (1) Patil,Moreshwar Pandharinath (1) Ramasamy,Thiruganesh (1) Ruttala,Himabindhu (1) Shanmugam,Suresh (1) Swain,Suryakanta (1) Mais... Palavra-chave In vitro dissolution (3) Aceclofenac/release colon targeted (1) Chronotherapeutics (1) Colon targeting (1) Drugs/release colon targeted (1) Eudragit coating (1) Gliclazide (1) Minimum inhibitory concentration (1) Polyethylene glycol 6000 (1) Solid dispersion (1) Targeted delivery (1) Time-dependent release (1) Xanthan gum (1) Zone of inhibition (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2012 (1) 2011 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Formulation and evaluation of xanthan gum based aceclofenac tablets for colon targeted drug delivery BJPS Ramasamy,Thiruganesh; Kandhasami,Uma Devi Subbaih; Ruttala,Himabindhu; Shanmugam,Suresh. The objective of the present study is to develop a colon targeted drug delivery systems for Aceclofenac using xanthan gum as a carrier. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of Aceclofenac. The xanthan gum, the drug and the physical mixture were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). All the formulations were evaluated for hardness, drug content uniformity and other physical properties. Release aspects of Aceclofenac in simulated gastrointestinal fluid and colonic fluid with enzymes were investigated. From these results,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/release colon targeted; Aceclofenac/release colon targeted; Xanthan gum; Colon targeting; Eudragit coating; In vitro dissolution; Targeted delivery. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200011 Antimicrobial activity assessment of time-dependent release bilayer tablets of amoxicillin trihydrate BJPS Beg,Sarwar; Nayak,Amit Kumar; Kohli,Kanchan; Swain,Suryakanta; Hasnain,MS. The aim of present study was the assessment of antimicrobial activity of prepared time-dependent release bilayer tablets of amoxicillin trihydrate and in vitro evaluation of drug release by antimicrobial assay using agar plate diffusion method. The bilayer tablets comprised of a delayed and sustained release layer. Direct compression method was used for the preparation of bilayer tablets containing Eudragit-L100 D55 as delayed release polymer, and HPMCK4M and HPMCK15 as sustained release polymers. The prepared bilayer tablets containing amoxicillin trihydrate were evaluated for hardness, thickness, friability, weight variation and drug content. Further, in vitro drug release was assessed by antimicrobial assay using S. aureus and E. coli as test... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronotherapeutics; Time-dependent release; In vitro dissolution; Minimum inhibitory concentration; Zone of inhibition. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200010 Characterization of gliclazide-polyethylene glycol solid dispersion and its effect on dissolution BJPS Patil,Moreshwar Pandharinath; Gaikwad,Naresh Janardan. The present study was initiated with the objective of studying the in vitro dissolution behavior of gliclazide from its solid dispersion with polyethylene glycol 6000. In this work, a solid dispersion of gliclazide with polyethylene glycol was prepared by the fusion method. In vitro dissolution study of gliclazide, its physical mixture and solid dispersion were carried out to demonstrate the effect of PEG 6000. Analytical techniques of FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry were used to characterize the drug in the physical mixtures and solid dispersions. The dissolution studies of solid dispersion and physical mixture showed greater improvement compared to that of the pure drug. The mechanisms for increased... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gliclazide; Polyethylene glycol 6000; Solid dispersion; In vitro dissolution. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100020 Registros recuperados: 3 Primeira ... 1 ... Última

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