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Green, Timothy J.; Rolland, Jean-luc; Vergnes, Agnes; Raftos, David; Montagnani, Caroline. |
The host-pathogen interactions between the Pacific oyster (Crassostrea gigas) and Ostreid herpesvirus type 1 (OsHV-1) are poorly characterised. Herpesviruses are a group of large, DNA viruses that are known to encode gene products that subvert their host’s antiviral response. It is likely that OsHV-1 has also evolved similar strategies as its genome encodes genes with high homology to C. gigas inhibitors of apoptosis (IAPs) and an interferon-stimulated gene (termed CH25H). The first objective of this study was to simultaneously investigate the expression of C. gigas and OsHV-1 genes that share high sequence homology during an acute infection. Comparison of apoptosis-related genes revealed that components of the extrinsic apoptosis pathway (TNF) were... |
Tipo: Text |
Palavras-chave: Crassostrea; Anti-viral response; Apoptosis; Interferon-like; Poly I:C. |
Ano: 2015 |
URL: http://archimer.ifremer.fr/doc/00279/39048/37610.pdf |