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Façanha,Mônica C.; Gondim,Argina M.B.; Pinheiro,Valéria G.F.; Barroso,Elizabeth C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A.M.. |
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p < 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59)... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tuberculosis; Bioavailability of antimycobacterial drugs; Intestinal barrier function; Rifampin; Isoniazid and pyrazinamide. |
Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011 |
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