|
|
|
|
|
| Pinheiro,Valéria G. F.; Ramos,Lysiane M. A.; Monteiro,Helena S. A.; Barroso,Elizabeth C.; Bushen,Oluma Y.; Façanha,Mônica C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A. M.. |
| Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pulmonary tuberculosis; Intestinal permeability; Rifampin and isoniazid intestinal malabsorption; M. tuberculosis resistance. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600003 |
| |
|
|
| Freitas,A.K.L.; Silva,M.T.B.; Silva,C.M.S.; Prata,M.M.G.; Rodrigues,F.A.P.; Siqueira,R.J.B.; Lima,A.A.M.; Santos,A.A.; Havt,A.. |
| Strenuous exercise triggers deleterious effects on the intestinal epithelium, but their mechanisms are still uncertain. Here, we investigated whether a prolonged training and an additional exhaustive training protocol alter intestinal permeability and the putative effect of alanyl-glutamine (AG) pretreatment in this condition. Rats were allocated into 5 different groups: 1) sedentary; 2 and 3) trained (50 min per day, 5 days per week for 12 weeks) with or without 6 weeks oral (1.5 g/kg) AG supplementation; 4 and 5) trained and subjected to an additional exhaustive test protocol with or without oral AG supplementation. Venous blood samples were collected to determine gasometrical indices at the end of the 12-week protocol or after exhaustive test. Lactate... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Claudin-2; Intestinal permeability; Lactulose-mannitol test; Physical exercise; Tight junctions. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500602 |
| |
|
|
| Werneck-Silva,A.L.; Sipahi,A.M.; Damião,A.O.M.C.; Buchpigue,C.A.; Iriya,K.; Laudanna,A.A.. |
| The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid (51Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of 51Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intestinal permeability; 51Cr-EDTA; Strongyloidiasis; Small bowel. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300009 |
| |
|
|
| Leite,A.Z.A.; Sipahi,A.M.; Damião,A.O.M.C.; Garcez,A.T.; Buchpiguel,C.A.; Lopasso,F.P.; Lordello,M.L.L.; Agostinho,C.L.O.; Laudanna,A.A.. |
| The pathogenesis of nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a complex process involving the uncoupling of mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase (COX). Rofecoxib, a selective inhibitor of COX-2, has shown less gastric damage, but the same beneficial effect is not clear in the case of the small bowel. Fifty-seven male Wistar rats (250-350 g) were divided into three groups (N = 19 each) to evaluate the effect of this NSAID on the rat intestine. The groups received 2.5 mg/kg rofecoxib, 7.5 mg/kg indomethacin or water with 5% DMSO (control) given as a single dose by gavage 24 h before the beginning of the experiment. A macroscopic score was used to quantify intestinal lesions and intestinal permeability was... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Intestinal permeability; Enteropathy; Nonsteroidal anti-inflammatory drugs; Indomethacin; Rofecoxib; COX-2 inhibitor. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300007 |
| |
|
| |
|
| |
|
|
|
