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| Peter,C.M.; Waller,S.B.; Picoli,T.; Osório,L.G.; Zani,J.L.; Meireles,M.C.A.; Faria,R.O.; Mello,J.R.B.; Hubner,S.O.; Lima,M.; Fischer,G.. |
| ABSTRACT In this study, we described the antifungal activity of three Brazilian propolis extracts: brown, green and from jataí bees against Sporothrix brasiliensis. The extracts were obtained from ethanolic extraction and their chemical composition was determined by high-performance liquid chromatography coupled to mass spectrometry. The cellular toxicity was measured in MDBK (Madin-Darby Bovine Kidney) cells and quantified by the MTT assay (3- (4,5 dimethylthiazol-2yl -2,5-diphenyl-2H bromine tetrazolato). For antifungal activity, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined by broth microdilution. The results showed that cell toxicity was not observed at lower concentrations (0.097 to 0.39μg/ml)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zoonosis; Itraconazole; Antifungal resistance; Therapeutic alternative. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000300819 |
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| Queiroz-Telles,Flávio; Silva,Nanci; Carvalho,Miriam M.; Alcântara,Ana Paula; Matta,Daniel da; Barberino,Maria G.; Bartczak,Sergio; Colombo,Arnaldo Lopes. |
| This study was a non-comparative multicenter clinical trial to evaluate the efficacy and tolerability of itraconazole oral solution 200 mg/day (100 mg twice a day in the fasting state) for the treatment of oropharyngeal candidiasis in AIDS patients. We included 50 patients who were treated and followed for up to 3 weeks after ending therapy in the analysis. Mycological cures at the end of therapy occurred in 20/50 patients (40%), but colonization by Candida sp. was recorded in 42/50 (84%) by the end of follow-up. A high rate of clinical response was observed in 46/50 (92%), and the response was sustained for up to 21 days after stopping therapy in 24/46 patients (52%). Clinical relapses were documented among 22 patients, but all causative fungal organisms... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS; Candidiasis; Itraconazole. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200003 |
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| Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa. |
| Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155 |
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| Waller,Stefanie Bressan; Nakasu,Ceres; Silva,Anna Luiza; Faria,Renata Osório de; Fernandes,João Paulo dos Santos; Cleff,Marlete Brum. |
| From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothrix brasiliensis isolates from cats (n=6) and standard strains of S. brasiliensis and S. schenckii were used to assess the antifungal activity of the POA derivatives through broth microdilution assay (CLSI M38-A2). Among the tested compounds, molecules 3 and 4 showed fungistatic and fungicidal activities against all Sporothrix spp. strains, and the obtained MIC and MFC values ranged from 2.12 to 4.24 mg/mL and from 1.29 to 5.15 mg/mL, respectively. Compound 2 and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sporotrichosis; Sporothrix schenckii complex; Itraconazole; Antifungal resistance; Prodrugs; Pyrazinoic acid derivatives. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400630 |
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