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| Celestino,Maísa Teodoro; Magalhães,Uiaran de Oliveira; Fraga,Aline Guerra Manssour; Carmo,Flávia Almada do; Lione,Viviane; Castro,Helena Carla; Sousa,Valeria Pereira de; Rodrigues,Carlos Rangel; Cabral,Lucio Mendes. |
| Antioxidants are currently used as efficient excipients that delay or inhibit the oxidation process of molecules. Excipients are often associated with adverse reactions. Stability studies can guide the search for solutions that minimize or delay the processes of degradation. The ability to predict oxidation reactions in different drugs is important. Methods: This study was conducted to assess the rational use of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), sodium metabisulfite (SMB), propyl gallate (PG) and cysteine (CYS) in tablet formulations of simvastatin and ketoconazole. These antioxidants were evaluated according to stability parameters and the relationship between efficiency of the antioxidant and chemical structure of the drugs.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidants/rational use; Excipients/evaluation; Butylated hydroxyanisole/rational use; Butylated hydroxytoluene/rational use; Sodium metabisulfite/rational use; Propyl gallate/rational use; Cysteine/rational use; Simvastatin/tablets; Simvastatin/evaluation; Ketoconazole/tablets; Ketoconazole/evaluation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300007 |
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