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Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca Arq. Bras. Med. Vet. Zootec.
Madruga,G.M.; Ribeiro,A.P.; Magalhães,T.B.S.; Rondelli,L.A.S.; Furlan,F.H..
ABSTRACT This study aimed to evaluate the effect of the 0.15% sodium hyaluronate (SH) and of 0.5% carboxymethylcellulose (CMC) on tear film breakup time (TFBUT) in 10 healthy dogs and in 32 eyes of dogs with keratoconjunctivis sicca (KCS). In addition, the goblet cell density (GCD) of this population was quantified. TFBUT was assessed at baseline and at different time points following the instillation of SH and CMC. KCS was graded as mild, moderate, and severe. GCD were quantified from conjunctival biopsies. The number of GCD differed significantly between patients with mild and moderate KCS (P<0.01). TFBUT of healthy dogs increased only for 1 minute after treatment with SH (P<0.01). Regarding baseline and treatments, SH significantly increased TFBUT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Goblet cells; Tear stability; Lacrimomimetics; Instillations.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000501388
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Qualitative and quantitative tear film abnormalities in dogs Ciência Rural
Ribeiro,Alexandre Pinto; Brito,Fabio Luiz da Cunha; Martins,Bianca da Costa; Mamede,Fabrício; Laus,José Luiz.
Tear film disorders in dogs can be classified into quantitative or qualitative abnormalities, or both, and are commonly observed in daily clinical practice. Inadequate production of one or more tear film components can lead to variable degrees of ocular disorders, called keratoconjunctivitis sicca. Keratoconjunctivitis sicca in dogs has several causes, but in most cases the disease is idiopathic, with T lymphocytes playing a role. In veterinary medicine, the diagnosis is made based on the results of the Schirmer tear test. In this article, we review aspects related to the etiopathogenesis and diagnosis of keratoconjunctivitis sicca in dogs and discuss new therapeutic modalities for this disease.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dogs; Tear film; Keratoconjunctivitis sicca; Lacrimomimetics; Lacrimostimulants; Immunosuppressors.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000200048
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Ocular lubricants: what is the best choice? Ciência Rural
Araújo,Daniela Macedo Lins de; Galera,Paula Diniz.
ABSTRACT: Ocular lubricants are used to supplement one or more layers of the lacrimal film. They are often prescribed to treat keratoconjunctivitis sicca (KCS) and other diseases of ocular surface in humans. These lubricants may also protect the ocular surface and promote epithelial regeneration. The active component of ocular lubricants is the lubricating agent. The key properties of different lubricating agents are the electrolyte composition, osmolarity, and addition of preservatives. Although lacrimomimetics are not typically used to treat KCS in dogs, they can be used as an adjunctive therapy. Knowledge of the properties of lacrimomimetics will help in making the appropriate therapeutic choice.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lacrimomimetics; Ocular lubricants; Artificial tears; Keratoconjunctivitis sicca.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001102055
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