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| Ávila,Renato Ivan de; Ferreira,Camila Carvalho; Alvarenga,Cátia Belo Mattos; Vieira,Marcelo de Sousa; Cortez,Alane Pereira; Batista,Aline Carvalho; Costa,Elson Alves; Valadares,Marize Campos. |
| This study evaluated the safety of Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark hydroalcoholic extract (LPE) through acute and subchronic toxicological assessments in mice. In the acute toxicity evaluation, a single 2000 mg/kg oral dose of LPE was administered to mice and clinical observations were conducted for 14 days. For subchronic toxicity, LPE doses (6.25-1000 mg/kg) were administered orally for 28 days and biochemical, hematological, histopathological analyses and renal and liver expression of Ki-67 were carried out. The acute oral toxicity evaluation of LPE showed no toxicity in mice and it was was classified as category 5 (LD50>2000-5000 mg/kg). In a repeated dose 28-day toxicity study, LPE (100-1000 mg/kg) led to an increase in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mangava-brava; Lafoensia pacari/evaluation; Medicinal plant; Natural product. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100595 |
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