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	Provedor de dados BJMBR (1) Autor Dominguez,W.V. (1) Nicastri,A.L. (1) Prado,E.B.A. (1) Prado,M.J.B.A. (1) Palavra-chave Bence-Jones proteins (1) Endocytosis (1) Lambda light chain protein (1) Renal cell acidification (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 2002 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Nephrotoxicity of Bence-Jones proteins: interference in renal epithelial cell acidification BJMBR Nicastri,A.L.; Prado,M.J.B.A.; Dominguez,W.V.; Prado,E.B.A.. The aim of the present study was to evaluate the acidification of the endosome-lysosome system of renal epithelial cells after endocytosis of two human immunoglobulin lambda light chains (Bence-Jones proteins, BJP) obtained from patients with multiple myeloma. Renal epithelial cell handling of two BJP (neutral and acidic BJP) was evaluated by rhodamine fluorescence. Renal cells (MDCK) were maintained in culture and, when confluent, were incubated with rhodamine-labeled BJP for different periods of time. Photos were obtained with a fluorescence microscope (Axiolab-Zeiss). Labeling density was determined on slides with a densitometer (Shimadzu Dual-Wavelength Flying-Spot Scanner CS9000). Endocytosis of neutral and acidic BJP was correlated with acidic... Tipo: Info:eu-repo/semantics/other Palavras-chave: Bence-Jones proteins; Renal cell acidification; Endocytosis; Lambda light chain protein. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300011 Registros recuperados: 1 Primeira ... 1 ... Última

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