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| Botelho,Patrícia Borges; Fioratti,Cyntia Okoshi; Rogero,Marcelo Macedo; Barroso,Lucia Pereira; Bertolami,Marcelo Chiara; Castro,Inar Alves. |
| The objective of this study was to investigate whether differences in diet and in single-nucleotide polymorphisms (SNPs) found in paraoxonase-1 (PON-1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesterol ester transfer protein (CETP) and apolipoprotein E (APOE) genes, are associated with oxidative stress biomarkers and consequently with susceptibility of low-density cholesterol (LDL) to oxidation. A multivariate approach was applied to a group of 55 patients according to three biomarkers: plasma antioxidant activity, malondialdehyde and oxidized LDL (oxLDL) concentrations. Individuals classified in Cluster III showed the worst prognoses in terms of antioxidant activity and oxidative status. Individuals classified in Cluster I presented... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diet; Oxidative stress/biomarkers; Single-nucleotide polymorphism (SNPs); Lipoproteins/oxidation; Statins; Apolipoprotein E. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100005 |
