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Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models BJMBR
Sousa,A.M.; Ashmawi,H.A.; Costa,L.S.; Posso,I.P.; Slullitel,A..
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tramadol; Tramadol-N-oxide; Rats; Peripheral nerves; Local anesthesia; Analgesia.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200009
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