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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor Brunetti,Iguatemy L. (1) Carneiro,R.C.G. (1) Chamone,D.A.F. (1) Dorlhiac-Llacer,P.E. (1) Khalil,Najeh M. (1) Maranhão,R.C. (1) Marquezini,M.V. (1) Oliveira,Olga M.M.F. (1) Toffoletto,O. (1) Mais... Palavra-chave Low-density lipoprotein (2) Acute myelogenous leukemia (1) Cytotoxicity (1) Daunorubicin (1) Hypochlorous acid (1) LDE complex (1) Methyl linoleate (1) Myeloperoxidase (1) Nicotine (1) RT-PCR (1) Tryptophan (1) Vitamin E (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system Anais da ABC (AABC) Oliveira,Olga M.M.F.; Brunetti,Iguatemy L.; Khalil,Najeh M.. In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nicotine; Myeloperoxidase; Hypochlorous acid; Low-density lipoprotein; Methyl linoleate; Vitamin E; Tryptophan. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183 In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells BJMBR Dorlhiac-Llacer,P.E.; Marquezini,M.V.; Toffoletto,O.; Carneiro,R.C.G.; Maranhão,R.C.; Chamone,D.A.F.. Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P<0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these drugs to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytotoxicity; Acute myelogenous leukemia; Daunorubicin; Low-density lipoprotein; LDE complex; RT-PCR. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000004 Registros recuperados: 2 Primeira ... 1 ... Última

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