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	Provedor de dados BJMBR (2) Autor Cai,X.Z. (1) Chen,D. (1) Chen,Y. (1) Dou,L.Y. (1) Du,S.Y. (1) Goldberg,A.C. (1) Huang,W.Y. (1) Jiang,Y. (1) Kiss,M.H.B. (1) Liphaus,B.L. (1) Liu,N. (1) Qiao,Y. (1) Yu,S. (1) Mais... Palavra-chave Lupus nephritis (2) Systemic lupus erythematosus (2) HLA-DRB1 alleles (1) Human leukocyte antigen (1) Juvenile-onset lupus (1) T-helper cell (1) TIM-3 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations BJMBR Liphaus,B.L.; Kiss,M.H.B.; Goldberg,A.C.. Human leukocyte antigens (HLA) DRB1*03 and DRB1*02 have been associated with systemic lupus erythematosus (SLE) in Caucasians and black populations. It has been observed that certain HLA alleles show stronger associations with SLE autoantibodies and clinical subsets, although they have rarely been associated with lupus renal histologic class. In the present study, HLA-DRB1 allele correlations with clinical features, autoantibodies and renal histologic class were analyzed in a cohort of racially mixed Brazilian patients with juvenile-onset SLE. HLA-DRB1 typing was carried out by polymerase chain reaction amplification with sequence-specific primers using genomic DNA from 55 children and adolescents fulfilling at least four of the American College of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic lupus erythematosus; Human leukocyte antigen; Lupus nephritis; Juvenile-onset lupus; HLA-DRB1 alleles. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400019 Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus BJMBR Cai,X.Z.; Huang,W.Y.; Qiao,Y.; Chen,Y.; Du,S.Y.; Chen,D.; Yu,S.; Liu,N.; Dou,L.Y.; Jiang,Y.. The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients... Tipo: Info:eu-repo/semantics/article Palavras-chave: TIM-3; Systemic lupus erythematosus; Lupus nephritis; T-helper cell. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100077 Registros recuperados: 2 Primeira ... 1 ... Última

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