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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Bai,R.X. (1) Dong,Xue-Song (1) Li,C.B. (1) Song,Chun-Qing (1) Sun,Da-Zhuang (1) Wang,W.P. (1) Xu,Yong-Min (1) Zhao,P.W. (1) Mais... Palavra-chave Apoptosis (2) MAPKs (2) A549 cells (1) Ghrelin (1) HO-8910 (1) Mitochondria (1) Paraquat (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Role of the MAPK pathway in human lung epithelial-like A549 cells apoptosis induced by paraquat Genet. Mol. Biol. Sun,Da-Zhuang; Song,Chun-Qing; Xu,Yong-Min; Dong,Xue-Song. Abstract This study aims to investigate the value of mitogen-activated protein kinases (MAPKs) for paraquat (PQ)-induced apoptosis in human lung epithelial-like A549 cells and the specific mechanism. A549 cell apoptosis were induced by PQ. These cells were divided into six groups: control group (cells were cultured in RPMI-1640 medium); SP600125 group (cells were preconditioned with SP600125); SB203580 group (cells were preconditioned with SB203580); PQ group (cells were treated with PQ); SP600125+PQ group (cells were preconditioned with SP600125 following PQ); SB203580+PQ group (cells were preconditioned with SB203580 following PQ). The cell survival rate, apoptosis rate, and activities of caspase-3 and -9 were detected. When compared with the control... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paraquat; A549 cells; MAPKs; Mitochondria; Apoptosis. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400701 Ghrelin attenuates the growth of HO-8910 ovarian cancer cells through the ERK pathway BJMBR Bai,R.X.; Wang,W.P.; Zhao,P.W.; Li,C.B.. Ovarian cancer is one of the most common causes of death from gynecologic tumors and is an important public health issue. Ghrelin is a recently discovered bioactive peptide that acts as a natural endogenous ligand of the growth hormone secretagogue receptor (GHSR). Several studies have identified the protective effects of ghrelin on the mammalian reproductive system. However, little research has been done on the effects of ghrelin on ovarian cancer cells, and the underlying mechanisms of these effects. We sought to understand the potential involvement of mitogen-activated protein kinases (MAPKs) in ghrelin-mediated inhibition of growth of the ovarian line HO-8910. We applied different concentrations of ghrelin and an inhibitor of the ghrelin receptor... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ghrelin; MAPKs; HO-8910; Apoptosis. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300602 Registros recuperados: 2 Primeira ... 1 ... Última

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