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Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders BJMBR
Oliveira,R.M.W.; Guimarães,F.S.; Deakin,J.F.W..
Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains a high density of NMDA receptors and nNOS-expressing neurons suggesting the existence of an NMDA-NO transduction pathway which can be involved in the pathogenesis of affective disorders. We tested the hypothesis that nNOS expression is increased in the human hippocampus from affectively ill patients. Immunocytochemistry was used to demonstrate nNOS-expressing neurons in sections obtained from the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Affective disorders; Major depression; Neuronal nitric oxide synthase; Immunohistochemistry; Hippocampus.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000400012
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Effect of aerobic training on EEG alpha asymmetry and depressive symptoms in the elderly: a 1-year follow-up study BJMBR
Deslandes,A.C.; Moraes,H.; Alves,H.; Pompeu,F.A.M.S.; Silveira,H.; Mouta,R.; Arcoverde,C.; Ribeiro,P.; Cagy,M.; Piedade,R.A.M.; Laks,J.; Coutinho,E.S.F..
The effect of physical exercise on the treatment of depressive elderly adults has not been investigated thus far in terms of changes in cortical hemispheric activity. The objective of the present study was to identify changes in depressive symptoms, quality of life, and cortical asymmetry produced by aerobic activity. Elderly subjects with a diagnosis of major depressive disorder (DSM-IV) were included. Twenty patients (70% females, 71 ± 3 years) were divided into an exercise group (pharmacological treatment plus aerobic training) and a control group (undergoing pharmacological treatment) in a quasi-experimental design. Pharmacological treatment was maintained stable throughout the study (antidepressants and anxiolytics). Subjects were evaluated by...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Alpha asymmetry; Quality of life; Depressive symptoms; Physical activity; Aerobic training; Major depression.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000600010
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