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| Desvignes, Thomas; Nguyen, Thaovi; Chesnel, Franck; Bouleau, Aurelien; Fauvel, Christian; Bobe, Julien. |
| Retinitis pigmentosa 2 (RP2) gene is responsible for up to 20% of X-linked retinitis pigmentosa, a severe heterogeneous genetic disorder resulting in progressive retinal degeneration in humans. In vertebrates, several bodies of evidence have clearly established the role of Rp2 protein in cilia genesis and/or function. Unexpectedly, some observations in zebrafish have suggested the oocyte-predominant expression of the rp2 gene, a typical feature of maternal-effect genes. In the present study, we investigate the maternal inheritance of rp2 gene products in zebrafish eggs in order to address whether rp2 could be a novel maternal-effect gene required for normal development. Although both rp2 mRNA and corresponding protein are expressed during oogenesis, rp2... |
| Tipo: Text |
Palavras-chave: Developmental biology; Egg developmental competence; Egg quality; Fish; Fish reproduction; Maternal-effect gene; Ndpk; Nme10; Oocyte; Oocyte-specific; Ovum; Teleost; Zygote. |
| Ano: 2015 |
URL: http://archimer.ifremer.fr/doc/00280/39099/37660.pdf |
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