|
|
|
|
|
| Wang,Z.K.; Yang,L.; Wu,L.L.; Mao,H.; Zhou,Y.H.; Zhang,P.F.; Dai,G.H.. |
| Colon cancer is one of the most common digestive tumors. The present study aimed to explore the functional role, as well as the underlying mechanism of long non-coding RNA LINC00261 in colon cancer. Expression of LINC00261 was analyzed in colon cancer cell lines and human normal cell lines. Acquired resistance cell lines were then built and the acquired resistance efficiency was detected by evaluating cell viability. Thereafter, the effects of LINC00261 overexpression on cisplatin-resistant colon cancer cells were measured, as well as cell apoptosis, viability, migration, and invasion. Subsequently, we investigated the interaction of LINC00261 and β-catenin. The results showed that the LINC00261 gene was down-regulated in colon cancer cell lines and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Colon cancer; LINC00261; Β-catenin; Cisplatin resistance; Mechanism. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200607 |
| |
|
|
| Tian,Meili; Yang,Shuang; Yan,Xinpeng. |
| Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining assay, wound healing assay, clonogenic assay, CCK-8 assay, and Annexin V-FITC/PI double staining method were carried out to determine the changes of HCT116 cell growth and migration. mRNA and protein expressions were determined by quantitative real-time PCR and western blot, respectively. Moreover, small interfering RNA (siRNA) plasmid was used to examine the role of p53 in icariin-induced apoptosis in HCT116 cells. Icariin significantly suppressed colon... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Colon carcinoma; Icariin; Mechanism; P53; DNA damage; Caspases. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000605 |
| |
|
|
| The concept of resilience is widely promoted as a promising notion to guide new approaches to ecosystem and resource management that try to enhance a system's capacity to cope with change. A variety of mechanisms of resilience specific for different systems have been proposed. In the context of resource management those include but are not limited to the diversity of response options and flexibility of the social system to adaptively respond to changes on an adequate scale. However, implementation of resilience-based management in specific real-world systems has often proven difficult because of a limited understanding of suitable interventions and their impact on the resilience of the coupled social-ecological system. We propose an agent-based modeling... |
| Tipo: Peer-Reviewed Reports |
Palavras-chave: Adaptive management; Agent-based model; Amudarya; Diversification; Fisheries; Irrigation; Mechanism; Resilience; River basin; Social-ecological system; Water use.. |
| Ano: 2007 |
|
| |
|
| |
|
| |
|
|
| Zhong-ming, Shen; Cheng-jun, Zhang. |
| The establishment of the three-dimensional interlocking professional management mechanism of agricultural family-owned enterprise was studied through the following three mechanisms; the stimulation and restriction mechanism within the agricultural family-owned enterprises, the credit mechanism of professional manager and the social environment mechanism. The relationship between the agricultural family-owned enterprise, professional manager and the society was studied. In the first place, the relationship between the agricultural family-owned enterprise and the professional manager belongs to the principal-agent relations, which means that the family-owned enterprise entrusts the professional manager with the operational rights and the professional... |
| Tipo: Journal Article |
Palavras-chave: Agricultural family-owned enterprise; The three-dimensional interlocking; Professional management; Mechanism; Agribusiness. |
| Ano: 2010 |
URL: http://purl.umn.edu/93237 |
| |
|
|
|
