|
|
|
|
| |
|
|
| Solon,Lílian Grace da Silva; Oliveira,Ana Isabel Maia de; Guerra,Gerlane Coelho Bernardo; Soares,Luiz Alberto Lira; Araújo,Aurigena Antunes de. |
| The aim of this study was to evaluate the quality of five different solid formulations of carbamazepine. The reference formulation was Tegretol® 200.00 mg (Novartis) and the others were: generic formulation of carbamazepine 200.00 mg (National Industry), similar formulation of carbamazepine 200.00 mg (National Industry), and two formulations of carbamazepine 200.00 mg acquired from two different compounding pharmacies. The latter consisted of capsules obtained in Natal, the capital city of the Brazilian State of Rio Grande do Norte. The quality of samples was evaluated through physical and physical-chemical tests, including: weight, diameter, thickness, content, dissolution, disintegration, hardness, friability and moisture. The results of friability... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carbamazepine; Medicines/quality control; Generic medicines; Similar medicines; Medicines/magistral formulation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300014 |
| |
|
|
| Santos,Olímpia Maria Martins; Reis,Maria Esther Dias; Jacon,Jennifer Tavares; Lino,Mônica Esselin de Sousa; Simões,Juliana Savioli; Doriguetto,Antonio Carlos. |
| Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polymorphism; Medicines/quality control; Medicines/solubility; Medicines/bioavailability. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100002 |
| |
|
|
| Araújo,Adriano Antunes Souza; Bezerra,Marília dos Santos; Storpirtis,Sílvia; Matos,Jivaldo do Rosário. |
| The determination of chemical purity, melting range, and variation of enthalpy in the process of characterizing medicines is one of the principal requirements evaluated in quality control of the pharmaceutical industry. In this study, the method of purity determination using DSC was outlined, as well as the application of this technique for the evaluation of commercial samples of zidovudine (AZT) (raw material) supplied by different laboratories. To this end, samples from six different laboratories (A, B, C, D, E, and F) and the standard reference (R) from the United States Pharmacopeia (USP) were analyzed. The DSC curves were obtained in the temperature range of 25 to 200 ºC under the dynamic atmosphere of N2 (50 mL min-1), heating rate of β=2 ºC min-1,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zidovudine/purity determination; Differential scanning calorimetry; Thermal analysis; Medicines/quality control; Medicines/qualitative analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100005 |
| |
|
| |
|
| |
|
| |
|
|
| Nascimento,Guilherme Nobre Lima do; Rosa,Daniel Lerner da; Nishijo,Hisao; Aversi-Ferreira,Tales Alexandre. |
| Ciprofibrate is a drug indicated in cases of hypertriglyceridemia and mixed hyperlipidemia, but no monographs are available in official compendia for the analysis of this substance in tablets. The objective of this work was to develop and validate a spectrophotometric method for routine analysis of ciprofibrate in tablets. In this study, commercial and standard ciprofibrate were used, as well as placebo in absolute ethanol, analyzed by UV spectrophotometer. All tests followed the rules of Resolution RE-899, 2003. The results showed that the developed and validated method offers low cost, easy implementation, precision and accuracy, and may be included in the routine of quality control laboratories. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ciprofibrate/analysis; Spectrophotometric method/medicines analysis; Medicines/quality control. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100004 |
| |
|
|
|
