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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Dabrundashvili,Nino (1) Guimarães,F.S. (1) Kalandadze,Irine (1) Mikeladze,David (1) Molchanov,M.L. (1) Shanshiashvili,Lali (1) Tsitsilashvili,Elene (1) Mais... Palavra-chave Metabotropic glutamate receptors (2) Defense behavior (1) HMGB1 (1) IL-10 (1) Inflammation (1) Macrophages (1) Open-field (1) Periaqueductal gray (1) Rats (1) T-ACPD (1) Mais... Tipo do documento Info:eu-repo/semantics/other (1) Journal article (1) Ano 2017 (1) 1999 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Metabotropic glutamate receptor 5 may be involved in macrophage plasticity Biol. Res. Shanshiashvili,Lali; Tsitsilashvili,Elene; Dabrundashvili,Nino; Kalandadze,Irine; Mikeladze,David. Abstract Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity. To investigate the role of glutamatergic systems in macrophages physiology, we performed the transfection of mGluR5 cDNAs into RAW-264.7 cells. Results Comparative analysis of modified (RAW-mGluR5 macrophages) and non-modified macrophages (RAW-macrophages) has shown that the RAW-mGluR5 macrophages absorbed more glutamate than control cells and the amount of intracellular glutamate correlated with the expression of excitatory amino acid transporters -2 (EAAT-2). Besides, our results have shown that... Tipo: Journal article Palavras-chave: Macrophages; Metabotropic glutamate receptors; Inflammation; HMGB1; IL-10. Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100203 Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats BJMBR Molchanov,M.L.; Guimarães,F.S.. The behavioral effects of trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9% (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P<0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P<0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a... Tipo: Info:eu-repo/semantics/other Palavras-chave: Periaqueductal gray; Metabotropic glutamate receptors; Defense behavior; T-ACPD; Open-field; Rats. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200013 Registros recuperados: 2 Primeira ... 1 ... Última

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