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| Sacher,Johannes; Saa,Pedro; Cárcamo,Martín; López,Javiera; Gelmi,Claudio A; Pérez-Correa,Ricardo. |
| Background: Calibration of dynamic models in biotechnology is challenging. Kinetic models are usually complex and differential equations are highly coupled involving a large number of parameters. In addition, available measurements are scarce and infrequent, and some key variables are often non-measurable. Therefore, effective optimization and statistical analysis methods are crucial to achieve meaningful results. In this research, we apply a metaheuristic scatter search algorithm to calibrate a solid substrate cultivation model. Results: Even though scatter search has shown to be effective for calibrating difficult nonlinear models, we show here that a posteriori analysis can significantly improve the accuracy and reliability of the estimation.... |
| Tipo: Journal article |
Palavras-chave: Gibberella fujikuroi; Gibberellic acid; Global optimization; Metaheuristics; Nonlinear dynamic models; Parameter estimation; Solid substrate cultivation. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000500007 |
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