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	Provedor de dados BJMBR (2) Autor Aizenstein,M.L. (1) Bukstein,O. (1) Carneiro-de-Oliveira,P.E. (1) DeLucia,R. (1) Justo,C.C. (1) Katz,B. (1) Pechansky,F. (1) Planeta,C.S. (1) Rohde,L.A. (1) Ruaro,P. (1) Schaefer,T. (1) Szobot,C.M. (1) Walcher,M. (1) Mais... Palavra-chave Methylphenidate (2) Adolescent rats (1) Adolescents (1) Attention deficit/hyperactivity disorder (1) Behavioral sensitization (1) Nicotine (1) Substance use disorder (1) Treatment (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder BJMBR Szobot,C.M.; Rohde,L.A.; Katz,B.; Ruaro,P.; Schaefer,T.; Walcher,M.; Bukstein,O.; Pechansky,F.. Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attention-deficit/hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, single-blind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression... Tipo: Info:eu-repo/semantics/article Palavras-chave: Attention deficit/hyperactivity disorder; Methylphenidate; Substance use disorder; Treatment; Adolescents. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300012 Repeated exposure of adolescent rats to oral methylphenidate does not induce behavioral sensitization or cross-sensitization to nicotine BJMBR Justo,C.C.; Carneiro-de-Oliveira,P.E.; DeLucia,R.; Aizenstein,M.L.; Planeta,C.S.. Several lines of evidence indicate that the use of stimulant drugs, including methylphenidate (MPD), increases tobacco smoking. This has raised concerns that MPD use during adolescence could facilitate nicotine abuse. Preclinical studies have shown that repeated treatment with an addictive drug produces sensitization to that drug and usually cross-sensitization to other drugs. Behavioral sensitization has been implicated in the development of drug addiction. We examined whether repeated oral MPD administration during adolescence could induce behavioral sensitization to MPD and long-lasting cross-sensitization to nicotine. Adolescent male Wistar rats were treated orally with 10 mg/kg MPD or saline (SAL) from postnatal day (PND) 27 to 33. To evaluate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylphenidate; Nicotine; Behavioral sensitization; Adolescent rats. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700007 Registros recuperados: 2 Primeira ... 1 ... Última

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