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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor CHEN,SONGLIN (1) Chen,S.S. (1) Cui,Z.Y. (1) DUAN,SILIANG (1) GAO,XINGXIN (1) HUANG,JINGJING (1) HUANG,XIAOQI (1) LI,MINGFEN (1) LI,PING (1) LIN,YINGHUI (1) Li,H. (1) Li,Y. (1) Ma,J. (1) PAN,AIPING (1) YANG,LEI (1) Zhang,Z.W. (1) Mais... Palavra-chave MiR-122 (2) Apoptosis (1) Cardiomyocyte (1) Caspase-8 (1) Hepatitis B cells (1) Inhibit (1) Myocardial infarction (1) Signaling pathway (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Inhibitory Effect on the Hepatitis B Cells through the Regulation of miR-122-MAP3K2 signal pathway Anais da ABC (AABC) CHEN,SONGLIN; YANG,LEI; PAN,AIPING; DUAN,SILIANG; LI,MINGFEN; LI,PING; HUANG,JINGJING; GAO,XINGXIN; HUANG,XIAOQI; LIN,YINGHUI. Abstract: The aim of this study was to investigate the inhibitory effect of regulation of miR-122-MAP3K2 signal pathway on the hepatitis B cells. We detected the content of MAP3K2 from patients with HBV blood serum samples and analyzed the correlation between content of MAP3K2 and copies of HBV-DNA. Wound healing and Transwell assays were used to detect the function of cells from control group (wild type) and observer group (overexpresses miR-122). Secretion levels of HBsAg and MAP3K2 in the supernatant and level of MAP3K2 in cells were detected by ELISA and western blot, respectively. The results showed that there was a positive correlation between the copies of HBV-DNA and MAP3K2 in serum. In the assays involving detection of the number of HBV-DNA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B cells; MiR-122; Inhibit; Signaling pathway. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300703 MicroRNA-122 regulates caspase-8 and promotes the apoptosis of mouse cardiomyocytes BJMBR Zhang,Z.W.; Li,H.; Chen,S.S.; Li,Y.; Cui,Z.Y.; Ma,J.. Cardiomyocyte apoptosis plays key roles in the pathogenesis of heart diseases such as myocardial infarction. MicroRNAs are important regulators of gene expression, which are also involved in the regulation of cardiomyocyte apoptosis. However, cardiomyocyte apoptosis regulated by microRNA (miR)-122 is largely unexplored. The aim of this study focused on the role of miR-122 in cardiomyocyte apoptosis. Cardiomyocytes were isolated from neonatal mice and primarily cultured. MiR-122 mimic and inhibitor were transfected to cardiomyocytes and verified by qRT-PCR. Cell viability and apoptosis post-transfection were assessed by MTT assay and flow cytometry, respectively. Changes in expression of caspase-8 were quantified by qRT-PCR and western blot. Results showed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiomyocyte; Apoptosis; MiR-122; Caspase-8; Myocardial infarction. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200601 Registros recuperados: 2 Primeira ... 1 ... Última

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