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| Xiang,Rui; Lei,Han; Chen,Mianzhi; Li,Qinwei; Sun,Huan; Ai,Jianzhong; Chen,Tielin; Wang,Honglian; Fang,Yin; Zhou,Qin. |
| MicroRNAs (miRNAs) have gradually been recognized as regulators of embryonic development; however, relatively few miRNAs have been identified that regulate cardiac development. A series of recent papers have established an essential role for the miRNA-17-92 (miR-17-92) cluster of miRNAs in the development of the heart. Previous research has shown that the Friend of Gata-2 (FOG-2) is critical for cardiac development. To investigate the possibility that the miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation in mouse embryonic cardiomyocytes we initially used bioinformatics to analyze 3’ untranslated regions (3’UTR) of FOG-2 to predict the potential of miR-17-92 to target it. We used luciferase assays to demonstrate that miR-17-5p and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MicroRNAs; MiR-17-92; FOG-2; Proliferation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200007 |
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