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| Santos,Paula Gomes; Santos,Dilvani Oliveira; Seródio,Lilia Ribeiro; Marinho,Rachel de Souza; Rodrigues,Carlos Rangel; Cabral,Lucio Mendes; Pádula,Marcelo de; Sousa,Valéria Pereira de; Castro,Helena Carla. |
| The aim of this work is to review the most important topics about the antiophidic sera sterility, including obtaining methods, sterilization procedures and clean room control using Vital Brazil Institute (VBI) as an example. Bibliographical research was performed through Medline, Lilacs, PubMed, ISI and the Fundação Oswaldo Cruz - RJ and VBI Libraries, from 1960 to 2009. The antiophidic sera for human use are immunobiologic products produced in Brazil by three national laboratories, including VBI. Due to the parenteral use, these products should be sterile and pyrogen-free, which demands the microbiological control during the whole fabrication process. The sterility and pyrogen tests are important steps to ensure the quality and safety of these... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Microbiologic control; Antiophidic sera; Sterility test; Contaminants. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300004 |
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| Rodrigues,Paulo Hercilio Viegas. |
| The great interest for heliconias by the external market has placed this crop in a prominent position in the flower production chain. The small offer of healthy seedlings, however, the expansion of this activity. The presence of endophytic microorganisms such as Pseudomonas sp. represents an obstacle even for the evolution of heliconia tissue culture studies. Stem apices of Heliconia rauliniana were inoculated and analyzed in vitro to investigate the presence of endophytic microorganisms. An antibiotic analysis was also run for posterior microbiological control. The presence of Pseudomonas sp. and Klebsiella sp. in stem apices confirmed infection. Antibiotics such as chloramphenicol, cefotaxime and the association of both (chloramphenicol + cefotaxime) at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tissue culture; Microbiologic control; Endophytics. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162005000100013 |
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