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| Roque,Fátima; Rama,Ana Cristina; Sousa,João José; Pina,Maria Eugénia. |
| The purpose of this study is to develop and improve oral liquids formulations of sildenafil citrate for paediatric use. Four different formulations were developed, which are as follows: two aqueous solutions of sildenafil citrate (2.5 mg/mL), with or without preservatives, and two other solutions of sildenafil in simple syrup (1.25 mg/mL), with or without preservatives. All of the formulations were physically, chemically and microbiologically stable for three months. The results of the stability studies allowed for the optimisation of formulations without preservatives due to their simplicity and their similar stable conditions when compared to the formulations containing antimicrobials. The shelf life of both formulations was three months; however, upon... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chemical stability; Microbiological stability; Sildenafil citrate; Paediatric formulations. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200021 |
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| COSTA,Eveline de Alencar; SOUSA,Paulo Henrique Machado de; SIQUEIRA,Adriana Camurça Pontes; FIGUEIREDO,Evânia Altina Teixeira de; GOUVEIA,Sandro Thomaz; FIGUEIREDO,Raimundo Wilane de; MAIA,Carla Soraya Costa; GOMES,Deysilene Soares. |
| Abstract Three paste formulations were developed for four fruits: caja, murici with mango and pitanga, with differentiated percentages of fruit pulp, organic honey and gellan gum. Pulps, honey and fruit paste formulations were analyzed by antioxidant capacity, vitamin C and in vitro bioaccessibility. All formulations showed a high content of vitamin C, antioxidant action and the bioaccessibility. All the formulations were accepted regarding the overall impression, except MM3 (murici pulp:mango pulp:honey 50:50:00 and 0.25% gellan gum) and PI1 (pitanga pulp: honey 90:10 and 0.6% gellan gum). Therefore, fruit pastes are options to encourage consumption of tropical fruits of agro-biodiversity in the Brazilian Northeast. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Structured fruit; Antioxidant activity; Sensory acceptance; Microbiological stability; Bioaccessibility. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019000300667 |
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