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	Provedor de dados BJPS (3) Autor Alebiowu,Gbenga (1) Amin,Jinal (1) Nwachukwu,Nkemakolam (1) Ofoefule,Sabinus Ifeanyi (1) Ogunjimi,Abayomi Tolulope (1) Paradkar,Mansi (1) Mais... Palavra-chave Microcrystalline cellulose (3) Binder (1) Brittle fracture index (1) Compaction (1) Coprocessing (1) Drying methods (1) Ethyl cellulose (1) Eudragit S100 (1) Ex-vivo drug release study (1) Extrusion-spheronization (1) Gossypium herbaceum (1) Modified fluid bed coater (1) Neem gum (1) Paracetamol (1) Powder (1) Tensile strength (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2018 (1) 2010 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets BJPS Ogunjimi,Abayomi Tolulope; Alebiowu,Gbenga. A 2³ factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing of binders on the mechanical properties. The results obtained from this study suggest that the nature (i.e. plastic/elastic) and ratio of binders coprocessed together alter the influence of C and P on TS and BFI. Tipo: Info:eu-repo/semantics/article Palavras-chave: Coprocessing; Neem gum; Microcrystalline cellulose; Binder; Tensile strength; Brittle fracture index; Paracetamol. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200006 Formulation development and evaluation of colon targeted delayed release methotrexate pellets for the treatment of colonic carcinoma BJPS Paradkar,Mansi; Amin,Jinal. Colonic carcinoma is one of the most common internal malignancies and is the second leading cause of deaths in United States. Methotrexate (MTX) is a drug of choice in the treatment of colon cancer. The aim of the present research work was to develop and characterize colon targeted pellets of MTX for treatment of colonic carcinoma. The product and process parameters were optimized by screening methods. Pellets were prepared by extrusion spheronization using microcrystalline cellulose (MCC) as spheronizing aid and ethyl cellulose (EC) as release retardant in different ratio. Based on the physical appearance, sphericity and % in vitro drug release, batch P17 containing EC: MCC (3:7) was optimized for core pellets. The site specificity was obtained by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethyl cellulose; Microcrystalline cellulose; Eudragit S100; Extrusion-spheronization; Modified fluid bed coater; Ex-vivo drug release study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400608 Effect of drying methods on the powder and compaction properties of microcrystalline cellulose derived from Gossypium herbaceum BJPS Nwachukwu,Nkemakolam; Ofoefule,Sabinus Ifeanyi. The effect of drying method, a process variable, on the powder and compaction properties of microcrystalline cellulose (MCC) obtained from the partial acid hydrolysis of bleached alpha (α) cellulose content of matured linters of Gossypium herbaceum (GH) was investigated. A portion of the wet MCC obtained was fluid bed dried at 60 ± 1 ºC, inlet air of 30 m3 min-1 for 3 h (coded MCC-GossF). The second portion was lyophilized at - 45 ± 2 ºC for 6 h (coded MCC-GossL). The physicochemical, scanning electron micrographs, X ray diffraction patterns and micromeritic properties of the derived MCCs were determined using standard methods. The cohesiveness and compactibility of the powders were investigated using Kawakita model while the deformation and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gossypium herbaceum; Powder; Compaction; Drying methods; Microcrystalline cellulose. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100581 Registros recuperados: 3 Primeira ... 1 ... Última

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