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| Sitthichai,Iamsaard; Wannisa,Sukhorum; Apichakarn,Sampannang; Bungorn,Sripanidkulchai. |
| Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before co-administration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and... |
| Tipo: Journal article |
Palavras-chave: Androgen receptor (AR); Ki-67; Momordica cochinchinensis; Rats; Steroidogenic acute regulatory protein (StAR); Tyrosine testicular phosphorylated protein; Valproic acid. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030 |
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| Sukhorum,Wannisa; Sampannang,Apichakarn; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai. |
| This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm... |
| Tipo: Journal article |
Palavras-chave: Momordica cochinchinensis; Valproic acid; Male reproductive parameters; Testicular damage; Rats. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009 |
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