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Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata BJPS
García Delgado,Neivys; Frías Vázquez,Ana Iris; Cabrera Sánchez,Hiran; Soto del Valle,Roberto Menéndez; Sierra Gómez,Yusvel; Suárez Alfonso,Ana María.
The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87µg/ear, while...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dichotomaria obtusata/pharmacognosy; Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/antinociceptive activity; Mouse ear edema test; Writhing test.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100008
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