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	Provedor de dados Genet. Mol. Biol. (1) Autor Natarajan,Satheesh (1) Palavra-chave Antiviral inhibitor (1) Drug discovery (1) Multifunctional protein (1) NS3 (1) Protease (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2010 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus Genet. Mol. Biol. Natarajan,Satheesh. The development of novel therapeutic agents is essential for combating the increasing number of cases of dengue fever in endemic countries and among a large number of travelers from non-endemic countries. The dengue virus has three structural proteins and seven non-structural (NS) proteins. NS3 is a multifunctional protein with an N-terminal protease domain (NS3pro) that is responsible for proteolytic processing of the viral polyprotein, and a C-terminal region that contains an RNA triphosphatase, RNA helicase and RNA-stimulated NTPase domain that are essential for RNA replication. The serine protease domain of NS3 plays a central role in the replicative cycle of dengue virus. This review discusses the recent structural and biological studies on the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antiviral inhibitor; Drug discovery; Multifunctional protein; NS3; Protease. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200002 Registros recuperados: 1 Primeira ... 1 ... Última

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