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	Provedor de dados BJMBR (1) Autor Cicogna,A.C. (1) Franco,M. (1) Matsubara,B.B. (1) Matsubara,L.S. (1) Okoshi,M.P. (1) Palavra-chave Coronary vascular remodeling (1) Myocardial function (1) Papillary muscle (1) Pressure overload hypertrophy (1) Reparative fib (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 1997 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Myocyte necrosis is the basis for fibrosis in renovascular hypertensive rats BJMBR Okoshi,M.P.; Matsubara,L.S.; Franco,M.; Cicogna,A.C.; Matsubara,B.B.. The pathogenesis of fibrosis and the functional features of pressure overload myocardial hypertrophy are still controversial. The objectives of the present study were to evaluate the function and morphology of the hypertrophied myocardium in renovascular hypertensive (RHT) rats. Male Wistar rats were sacrificed at week 4 (RHT4) and 8 (RHT8) after unilateral renal ischemia (Goldblatt II hypertension model). Normotensive rats were used as controls. Myocardial function was analyzed in isolated papillary muscle preparations, morphological features were defined by light microscopy, and myocardial hydroxyproline concentration (HOP) was determined by spectrophotometry. Renal artery clipping resulted in elevated systolic arterial pressure (RHT4: 178 ± 19 mmHg and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary vascular remodeling; Myocardial function; Pressure overload hypertrophy; Papillary muscle; Reparative fib. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900013 Registros recuperados: 1 Primeira ... 1 ... Última

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